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The biomarkers associated with an increased risk of cardiovascular events include fibrinogen and endothelial dysfunction, as well as the cytokines IFN- and TNF-, and these two inflammatory markers have also been shown to be predictive of future cardiovascular events [28]

Rationale of the 3Ts Protocol PD is a localized fibrotic disorder of the tunica albuginea that progresses from an early inflammatory phase to a chronic fibrotic/calcified stage [2]

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